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April Journal of Molecular Endocrinology. July Bibcode : PNAS.. Medical Science Monitor. Endorphins affect us like codeine or morphine do, but without the addiction.
Regular users of opiates generally aren't models of emotional stability, and steady, controlled endorphin release is something of a pipe dream. Making matters worse, some of us have brains that act like ambitious drug dealers, and others of us only dabble now and then.
This variation can help explain why one person reacts differently from another to the same stimulus.
Endorphins have a leg up on opiates, however. Endorphins may be responsible for the "placebo effect," owing to the real response of endorphin-release prompted by a tricked hypothalamus, creating a sense of well-being after consuming a much-hyped sugar pill, or even after simply anticipating something pleasurable.
When endorphins lock into the opioid receptors, they are almost immediately broken down by enzymes, allowing them to be recycled and reused down the road.
However, when similarly shaped but chemically different opiates lock into these same receptors, they are resistant to the enzymes and continue reactivating the receptors over and over, extending the "high" and increasing euphoric feelings, as well as the likelihood of dependence.
Many things can trigger the release of endorphins. Though many triggers are known to exist which we'll discuss in a moment , the primary triggers are stress and pain.
When your hypothalamus detects pain, it issues several orders, one of them being, "Quit telling me it hurts! The hypothalamus is the command-and-control center of your endocrine system.
It decides when you need to eat, when you should begin puberty and when you need a big dose of endorphins, among many other functions.
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More research is needed to further understand the role that endorphins have in treating depression. Endorphins may play an important role in reducing stress and anxiety.
A study in mice showed a direct relationship between endorphin levels and anxious behavior in mice. More research studies in humans are needed.
Positive feelings also make you feel confident and optimistic, thus giving your self-esteem a boost. In one small study , endorphins were associated with high self-esteem in a small group of men.
Much larger studies are needed. The role of endorphins and other hormones in regulating your appetite and food intake is complex. While eating good food is thought in increase endorphin levels, higher levels of endorphins have also been shown in animal studies to help regulate the appetite.
More research in humans is needed to clarify these effects. Childbirth can be an incredibly rewarding, yet incredibly painful experience. Endorphins can make labor a bit easier.
A small study in 45 healthy women giving birth found that low levels of beta-endorphin at the end of pregnancy were associated with a need for additional pain treatment medications during labor.